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4-1BB RECEPTORS
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DeCS
Descriptor
English
:
Antigens, CD137
Descriptor
Spanish
:
Antígenos CD137
Descriptor
Portuguese
:
Antígenos CD137
Synonyms
English
:
4-1BB Receptors
CD137 Antigens
Tumor Necrosis Factor Receptor Superfamily, Member 9
Tree Number:
D12.776.543.750.705.852.760.220
D23.050.301.264.035.237
D23.101.100.110.237
Definition
English
:
A member of the tumor
necrosis
factor receptor superfamily that is specific for
4-1BB LIGAND
. It is found in a variety of immune cell types including activated
T-LYMPHOCYTES
; NATURAL KILLER CELLS; and
DENDRITIC CELLS
. Activation of the receptor on
T-LYMPHOCYTES
plays a role in their expansion, production of
cytokines
and
survival
. Signaling by the activated receptor occurs through its
association
with TNF RECEPTOR-ASSOCIATED FACTORS.
History Note
English
:
2007(1993)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
52384
Unique Identifier:
D053261
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS